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Apart from the small number of people who have reported improvement or resolution of emotional or personality problems after the use of MDMA in psychotherapy, the long-term effects are virtually all adverse ones. They are all thought to arise from a neurotoxic action of the methylenedioxy derivatives of the amphetamines. The reported effects of MDMA vary according to the dose and the frequency and duration of use. In general, the effects desired by most users are those produced by low doses on single occasions. It is, therefore, convenient to describe the effects separately for acute (single-occasion) and chronic (long-term) use and, within each category, to describe separately the mental and the physical effects. A third category of effect, consisting of the serious or fatal toxicity seen at higher doses or in abnormally sensitive individuals, will be described separately. Effects on the user You also consent to Asana Recovery contacting you by phone, text message, and email regarding your insurance benefits and treatment services. You acknowledge that text messaging may involve risks, authorize the use of your Protected Health Information (PHI) for these communications, and understand you can opt-out of text messages at any time by replying “STOP”. At Asana, we offer effective, insurance-covered treatment for addiction and mental health, guided by experts who understand because they’ve been there. Pure MDMA is typically a white or off-white powder or crystalline substance, though it may be sold in capsules or pressed pills. There’s no guaranteed way to confirm if molly is pure without laboratory testing. Reagent kits can help detect the presence of MDMA but don’t account for all potential additives. In 2023, more than 1.5 million adults in this age group used ecstasy compared with about 520,000 adults aged 18 to 25. At Asana, we offer effective, insurance-covered treatment for addiction and mental health, guided by experts who understand because they’ve been there. This will stop you from getting dehydrated and possibly fainting or feeling lightheaded. Other drugs in this chemical group include methamphetamine and cathinone. There are ongoing clinical studies to test how well this treatment might work. Where Is MDMA Made? The same phenomenon occurs with the classical hallucinogens, which have not proven to give rise to dependence to nearly the same extent as alcohol, cannabis, benzodiazepines or opioids, for example. On the other hand, amphetamine and methamphetamine are at least as liable to produce dependence as cocaine.2,58 It may be that the methylenedioxy group on the phenyl ring in MDA, MDMA and MDEA makes them more like mescaline than like the parent amphetamines in this respect, but prudence suggests that it would be best to reserve judgement on this point. MDMA (an abbreviation of 3,4-methylenedioxymethamphetamine), also called “Molly” or “Ecstasy,” is a lab-made (synthetic) drug that has effects similar to stimulants like methamphetamine. It is typically sold illicitly as colorful tablets with imprinted logos, capsules, powder, or liquid. Some researchers and organizations consider MDMA to be a psychedelic drug because it can also mildly alter visual and time perception. MDMA’s effects may include feeling more energetic and alert and having an increased sense of well-being, warmth, and openness toward others. While not addictive like heroin or cocaine, ecstasy use may lead to dependence. It’s similar to other stimulant drugs, such as methamphetamine. It also causes hallucinogenic effects that can change how you see the world, such as not knowing what time it is or seeing things that are not there. Ecstasy directly affects the levels of neurotransmitters in your brain, including serotonin, dopamine, and norepinephrine. On the whole, it is relatively mild, resembling a viral hepatitis, with jaundice, an enlarged tender liver, an increased bleeding tendency, raised liver enzyme levels in the blood and a biopsy picture of acute hepatitis that is not in any sense diagnostic of MDMA toxicity. Spontaneous recovery usually occurs over a period of a few weeks to many months, but in chronic users of MDMA there may be repeated attacks of hepatitis.103,104,107,108,109,110,111,112 Several authors have suggested that in any case of repeated acute hepatitis in a young person, the use of MDMA should be suspected as a possible cause. Andreu and colleagues103 found that in their hospital “ecstasy” was the second most common cause of liver injury in patients under the age of 25 years. Molly is supposed Ecstasy ingredients to be pure MDMA, but it is frequently cut with substances like methamphetamine, caffeine, synthetic cathinones, and other stimulants. Find Your First Step in Recovery, Supported by Shared Experience In addition to the high you get from ecstasy, the drug also causes many unpleasant and potentially dangerous side effects that affect your mind and your body. Call us today to learn more about our programs or to begin your journey to lasting recovery. As the name implies, MDMA is a derivative of methamphetamine (known by such street names as “speed,” “crystal” and “meth” among others) and its parent compound amphetamine. If you or someone you love is struggling with ecstasy or molly use, Asana Recovery offers evidence-based treatment designed to address both the physical and emotional aspects of addiction. For the treatment of PTSD, MDMA can only be prescribed by psychiatrists with specific training and authorisation.300In 1986, MDMA was declared an illegal substance because of its allegedly harmful effects and potential for misuse.301 Any non-authorised sale, use or manufacture is strictly prohibited by law. Permits for research uses on humans must be approved by a recognized ethics committee on human research. These figures indicate that the death rate from heroin is higher, but that the precision of the estimate is much lower for ecstasy, which probably reflects a more heterogeneous user population, with fewer ecstasy users being as risk seeking as some of the heroin users. Both drugs are supposed to contain MDMA, but are often mixed with methamphetamine, amphetamines, or bath salts. Potentially Dangerous Effects in the Body The emergency and referral resources listed above are available to individuals located in the United States and are not operated by the National

Physical signs of substance misuse often include changes in appearance and health status. Individuals may experience noticeable weight changes, bloodshot eyes, poor coordination, or unusual sleep patterns. They might also show signs specific to their substance of use, such as slurred speech, dilated pupils, or frequent illness and hangovers. These may include declining performance at work or school, financial problems, secretive behavior, or changes in social circles 3. You may want to reach out to a friend or loved one for support as you start your treatment journey. Their encouragement could be the motivation you need to talk to a healthcare provider. Taking some drugs can be particularly risky, especially if you take high doses or combine them with other drugs or alcohol. Despite the name, these are not bath products such as Epsom salts. Substituted cathinones can be eaten, snorted, inhaled or injected and are highly addictive. These drugs can cause severe intoxication, which results in dangerous health effects or even death. People use cannabis by smoking, eating or inhaling a vaporized form of the drug. Cannabis often precedes or is used along with other substances, such as alcohol or illegal drugs, and is often the first drug tried. The fact that this critical part of a teen’s brain is still a work in progress puts them at increased risk for trying drugs or continuing to take them. No matter where you are, know that this condition is treatable and help is available when you’re ready. The most common hallucinogens are lysergic acid diethylamide (LSD) and phencyclidine (PCP). While naloxone has been on the market for years, a nasal spray (Narcan, Kloxxado) and an injectable form are now available, though they can be very expensive. Science Updates The platform provides reliable resources, accessible services, and nurturing communities. Its purpose is to educate, support, and empower people in their pursuit of well-being. Integrated treatment approaches are essential for addressing co-occurring disorders effectively. This means treating both conditions simultaneously rather than addressing them separately. Research shows that integrated treatment leads to better outcomes than treating each condition in isolation 6. Additionally, cognitive function often suffers during active addiction. Introducing drugs during this period of development may cause brain changes that have profound and long-lasting consequences. Consider how a social drinker can become intoxicated, get behind the wheel of a car, and quickly turn a pleasurable activity into a tragedy that affects many lives. Occasional drug use, such as misusing an opioid to get high, can have similarly disastrous effects, including impaired driving and overdose. Use these free education and outreach materials in your community and on social media to spread the word about mental health and related topics. Recognizing the signs of addiction can be challenging, as the condition often develops gradually, and individuals may hide their symptoms. How are these co-occurring disorders diagnosed and treated? Substance use can trigger or worsen symptoms of mental health conditions, particularly anxiety and depression. Similarly, mental health challenges may lead to substance use as a form of self-medication, which continues the cycle. It may help to get an independent perspective from someone you trust and who knows you well. You can start by discussing your substance use with your primary care provider. Or ask for a referral to a specialist in drug addiction, such as a licensed alcohol and drug counselor, or a psychiatrist or psychologist. Changes in the brain The risk of addiction and how fast you become addicted varies by drug. Some drugs, such as opioid painkillers, have a higher risk and cause addiction more quickly than others. But with continued use, a person’s ability to exert self-control can become drug addiction substance use disorder symptoms and causes seriously impaired. If left untreated, they can last a lifetime and may lead to death. The latest information and resources on mental disorders shared on X, Facebook, YouTube, LinkedIn, and Instagram. Learn about NIMH priority areas for research and funding that have the potential to improve mental health care over the short, medium, and long term. Use these free digital, outreach materials in your community and on social media to spread the word about mental health. In general, the more risk factors a person has, the greater the chance that taking drugs will lead to drug use and addiction. Protective factors, on the other hand, reduce a person’s risk. Risk and protective factors may be either environmental or biological. Updates about mental health topics, including NIMH news, upcoming events, mental disorders, funding opportunities, and research. Further Reading NIMH offers expert-reviewed information on mental disorders and a range of topics. John C. Umhau, MD, MPH, CPE is board-certified in addiction medicine and preventative medicine. For over 20 years Dr. Umhau was a senior clinical investigator at the National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health (NIH). MentalHealth.com is a health technology company guiding people towards self-understanding and connection. Drug addiction, also called substance use disorder, is a disease that affects a person’s brain and behavior and leads to an inability to control the use of a legal or illegal drug or medicine. Substances such as alcohol, marijuana and nicotine also are considered drugs. When you’re addicted, you may continue using the drug despite the harm it causes. SUD medications If your drug use is out of control or causing problems, get help. The sooner you seek help, the greater your chances for a long-term recovery. Talk with your health care provider or see a mental health provider, such as a doctor who specializes in addiction medicine or addiction psychiatry, or a licensed alcohol and drug counselor. More In Conditions A-Z Group therapy supports people with SUD in maintaining abstinence and restraint. Their encouragement could be the motivation you need to talk to a healthcare provider. Follow-up care can include periodic appointments with your counselor, continuing in a self-help program or attending a regular group session. Many find success through support groups (like Narcotics Anonymous) and ongoing therapy. Two groups of synthetic